Rather, a quantitative fit between data and simulations supports alterations of an NMDAR-dependent memory mechanism operating on longer timescales, such as short-term potentiation. Changes in cortical excitation destabilized within-trial memory maintenance and could not account for disrupted serial dependence in working memory. We then simulated this finding with NMDAR-dependent synaptic alterations in a microcircuit model of prefrontal cortex. In both patient groups, we report a markedly reduced influence of previous stimuli on working memory contents, despite preserved memory precision. We first quantified shared working memory alterations in a delayed-response task. We propose a combined psychophysical and biophysical account of two symptomatologically related diseases, both linked to hypofunctional NMDARs: schizophrenia and autoimmune anti-NMDAR encephalitis. A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders.
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